Page 21 - CIBERES2016-ENG

• Transdifferentiation of endothelial cells to smooth muscle cells in vascular proliferation and remodelling.
• Haemodynamic characterisation in patients with COPD.
• Role of Fas ligand in acute pulmonary damage.
• Changes in expression and distribution of tight-junction proteins ZO1 and occludin in ARDS.
• Specific MicroRNAs induce endothelial dysfunction and ionic remodelling in pulmonary arteries.
• Brain-lung communication in the critical patient.
• Meaning of patient-ventilator asynchronies.
• Identification of the mechanisms involved in collective cell migration.
• Changes in 3D structure have a role in losing pulmonary compliance.
• Characterisation of vascular resistance in the decellularized lung.
NEW THERAPIES
• Telomerase-inhibiting peptides for treatment of PF.
• Acid sphingomyelinase and IL-6 inhibitors in PH and endotoxin-induced ventilation-perfusion
uncoupling.
• Quercetin flavonoid prevents pulmonary oedema in a haemorrhagic shock model.
• Anti-inflammatory effects of heparin and antithrombin III in human lung cells.
• Effectiveness of methotrexate in animal models of sepsis.
• Intestinal decontamination attenuates the inflammation induced by aggressive mechanical ventilation.
• Transplanting type II alveolar cells reduces alveolar-capillary permeability and cell infiltration.
• Therapy of combining ambrisentan and tadalafil in PH.
• Effectiveness of sildenafil in models of COPD and PF.
• Preclinical utility of ß3 adrenergic agonists in PH.
UTILITY MODELS AND INNOVATION
• New long-term ARDS models.
• Cell models with mutations of the telomerase complex of patients with idiopathic PF.
• Cultures of endothelial cells from endarterectomies.
• Administration protocols.
RES
Scientific Programmes 21