Page 37 - CIBERES2016-ENG

Most relevant scientific articles
• Marti S, Puig C, de la Campa AG, Tirado-Velez JM, Tubau F, Domenech A et al. Identification of Haemophilus haemolyticus in clinical samples and characterization of their mechanisms of antimicrobial resistance.The Journal of antimicrobial chemotherapy. 2016;71(1):80-4.
• Mell J.C., Viadas C., Moleres J., Sinha S., Fernandez-Calvet A., Porsch E.A. et al. Transformed Recombinant Enrichment Profiling Rapidly Identifies HMW1 as an Intracellular Invasion Locus in Haemophilus influenza. PLoS Pathogens. 2016;12(4).
• Munoz-Esquerre M., Lopez-Sanchez M., Escobar I., Huertas D., Penin R., Molina-Molina M. et al. Systemic and pulmonary vascular remodelling in chronic obstructive pulmonary disease. PLoS ONE. 2016;11(4).
• Grau I., Ardanuy C., Cubero M., Benitez M.A., Linares J., Pallares R. Declining mortality from adult pneumococcal infections linked to children’s vaccination. Journal of Infection. 2016-.
• Domenech A., Moreno J., Ardanuy C., Linares J., De La Campa A.G., Martin-Galiano A.J. A novel typing method for Streptococcus pneumoniae using selected surface proteins. Frontiers in Microbiology. 2016;7(MAR).
Highlights
The introduction of pneumococcal conjugate vaccines for childhood vaccination has been associated with a decrease in the young adult mortality due to invasive pneumococcal disease, showing herd protection. The surfotyping is a new approach for the study of pneumococcal diseases that use surface protein combinations to define pathogenic lineages.
“Transformed recombinant enrichment profiling” (TREP) is a new methodology for the analysis of the genetic basis of phenotypic variation in order to identify new targets for antimicrobial development. Among respiratory samples, the frequency of Haemophilus haemolyticus is low being most relevant in genital samples. Moreover, the antimicrobial resistance mechanisms of this emergent pathogen have been described.
In the 2016 call of “Acción Estratégica en Salud”, two new projects have been funded to study several aspects of COPD. The first one, based in omics tools will analyze the inflammatory markers in COPD. The second one will study the cardiovascular alterations and the vascular remodeling associated with this chronic disease.
A PhD thesis analyzing the virulence and resistance mechanisms of Klebsiella pneumoniae has been defended.
RES
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