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Most relevant scientific articles
• Quintero M., Olea E., Conde S.V., Obeso A., Gallego-Martin T., Gonzalez C. et al. Age protects from harmful effects produced by chronic intermittent hypoxia. Journal of Physiology. 2016;594(6):1773-1790.
• Masa J.F., Corral J., Romero A., Caballero C., Teran-Santos J., Alonso-Alvarez M.L. et al. The effect of supplemental oxygen in obesity hypoventilation syndrome. Journal of Clinical Sleep Medicine. 2016;12(10):1379-1388.
• Masa JF, Corral J, Romero A, Caballero C, Terán-Santos J, Alonso-Álvarez ML et al. Protective cardiovascular effect of sleep apnea severity in obesity hypoventilation syndrome.Chest. 2016.
Highlights
After the forced change of direction, our group has consolidated and matured with the following achievements:
• New IP, Ana Obeso.
• New funding: MINECO-FEDER project, BFU2015-70616R Pathophysiological implications of obstructive
sleep apnea: arterial hypertension and tumorigénesis.
• Incorporation of new researchers: Dr. Jesús Prieto Lloret, postdoctoral contractor; Dr. Elvira González
Obeso: specialist pathologist Hospital Universitario de Valladolid.
• Consolidation of collaborations with other intraCIBERES groups: Group 15, Group 12 and Group 28, with
publications in common.
• Three doctoral theses have been defended, by Miguel Quintero, Elena Olea and Teresa Gallego (this one
with international mention) directed by members of the group.
• We have been recognized as a Research Excellence Group (UIC) by the Junta de Castilla y León.
Our most relevant scientific achievements are summarized in the following points: Aging protects against the deleterious effects of chronic intermittent hypoxia on respiratory and cardiovascular function in a
rat model. We demonstrate for the first time that chronic intermittent hypoxia is a risk factor promoting
the spontaneous appearance of tumors in different tissues, and significantly in the lung, in a murine
aging model. Sexual dimorphism is confirmed in the onset and progression of pulmonary hypertension associated with chronic hypoxia in a rat model. The role of carotid body (CB) in glucose homeostasis and in insulin sensitivity in rat adipose and hepatic tissue has been demonstrated.
The group has collaborated in activities organized by CIBERES, participating (Asuncion Rocher as a member of the CIBERES Teaching Commission) in the organization of the 9th CIBERES Training Days, Collaborative Projects with CIBERBNN, held in the Auditorium of the National Cardiovascular Research Center Carlos III (CNIC), Madrid 29-30 September. We have organized (Ricardo Rigual) and participated as guest speaker (Ana Obeso) with the lecture: “From carotid body oxygen sensing to chronic intermittent hypoxia, effects on spontaneous tumorigenesis” in the symposium entitled: “A new role for the carotid body in pathology” at the XXXVIII Congress of the Spanish Society of Physiological Sciences, Zaragoza 13-16 September 2016. We have participated as guest speaker in the International Symposium on Acute Pulmonary Injury Translational Research, INSPIRES, Organized by the Intensive Care Unit (with members of CIBERES) held at the University Hospital of Getafe on November 2 and 3, 2016 invited speaker Ana Obeso. Title of the presentation: “Cell response to hypoxia”.
RES
research groups 81