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instillation of mesenquimal stem cells or type II alveolar cells in animal models of ALI.
• Clinical and experimental approach of the axis brain-lung during mechanical ventilation (CIBERES Groups 29
and 33; GTC I3A CIBER-BBN and SEPAR):
Molecular alterations in brain and lung during MV / Characterization of neuropsychological / psychopathology alterations and cognitive assessment in MV patients. / Integrity of the autonomic nervous system during VM collaboration with CIBER-BBN-SEPAR. / Feasibility, safety and efficacy of neurocognitive rehabilitation in patients with VM.
• Study of the patient-ventilator interaction during VM.
Most relevant scientific articles
• Hernandez G., Vaquero C., Gonzalez P., Subira C., Frutos-Vivar F., Rialp G. et al. Effect of postextubation high-flow nasal cannula vs conventional oxygen therapy on reintubation in low-risk patients: A randomized clinical trial. JAMA - Journal of the American Medical Association. 2016;315(13):1354-1361.
• Hernández G, Vaquero C, Colinas L, Cuena R, González P, Canabal A et. al. Effect of Postextubation High- Flow Nasal Cannula vs Noninvasive Ventilation on Reintubation and Postextubation Respiratory Failure in High-Risk Patients: A Randomized Clinical Trial.JAMA. 2016.
• Garcia-Prieto E., Lopez-Aguilar J., Parra-Ruiz D., Amado-Rodriguez L., Lopez-Alonso I., Blazquez-Prieto J. et al. Impact of Recruitment on Static and Dynamic Lung Strain in Acute Respiratory Distress Syndrome. Anesthesiology. 2016;124(2):443-452.
• Murias G., Montanya J., Chacon E., Estruga A., Subira C., Fernandez R. et al. Automatic detection of ventilatory modes during invasive mechanical ventilation. Critical Care. 2016;20(1).
• Puig F, Herrero R, Guillamat-Prats R, Gómez MN, Tijero J, Chimenti L et al. A New Experimental Model of Acid and Endotoxin-Induced Acute Lung Injury in Rats.American journal of physiology. Lung cellular and molecular physiology. 2016; ajplung.00390.2015.
Highlights
• Strategic Health Action ISCIII: Implementation of a “Smart Data Display” to support decision making in the critical patient. Application in patient-ventilator interaction and weaning from mechanical ventilation (PI16/01606). / Immunomodulatory cell therapy in sepsis (PI15/02204). / Influence of persistent patient/ ventilator decoupling on the cognitive and psychopathological status in the critical patient (PI13/02204): Characterization of asynchronies and cognitive/psychopathological alterations (1-24 months after ICU) in mechanically ventilated patients. Experimental model of asynchronies. / Alveolar type II cell transplant and experimental models of acute lung injury (PI12/02548): New experimental model of ALI and anti- inflammatory effect of transplanted AT2 cells (Catalan Society of Pulmonology Grant).
• Neurocognitive stimulation platform for patients undergoing mechanical ventilation: feasibility of innovation in Health Care (FIPSE), mentoring (MIT-Boston/Idea2Global) and business model (Inveniam).
• Effects of an early neurocognitive intervention on patient-ventilator interaction and stress/heart rate variability in patients receiving mechanical ventilation (Collaboration CIBERES-SEPAR-CIBERBBN).
• EU Projects: THALEA I / II “Telemonitoring and Telemedicine for Hospitals Assisted by ICT for Life saving co- morbid patients in Europe as part of a Patient personalized care program of the EU “.
• Anticoagulant treatment in experimental acute lung injury: Nebulized heparin reduces pulmonary coagulopathy and inflammation without producing systemic hemorrhage. Antithrombin III reduces inflammation in an cell culture in vitro model (Grifols).
• Multicenter clinical trials: ventilator-associated pneumonia, ARDS / ALI and strategies for mechanical ventilation.
• Weaning of mechanical ventilation: Prevention of the risk of reintubation in patients with low and high risk by the application of a high oxygen flow nasal cannula.
• Better Care® Middleware Platform (PCT / EP2008 / 052458) and Better Care Spin-off.
• Clinical guidelines (Reports of the Working Group of the World Federation of Societies of Intensive and Critical
research groups 43
Medicine): Triage for ICU admission, 2) critical care specialists and 3) Criteria for the initiation of invasive ventilation in septic shock.
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