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• Molecular links between COPD and Lung Cancer
Our group is interested in investigating the mechanistic relationships between COPD and the onset
of lung cancer, using both patient samples and animal models reproducing both entities. Our results indicate a series of differential characteristics present in patients with COPD who develop lung cancer.
• Pulmonary hypertension
Some researchers from our group are studying the risk and prognosis factors, as well as different pathophysiological characteristics (both at general and molecular levels) of primary pulmonary hypertension. However, we are also very interested in secondary pulmonary hypertension present in many COPD patients. Studies focusing on the development of exercise-induced pulmonary hypertension are a particular focus of our last studies.
Most relevant scientific articles
• Chacon-Cabrera A., Gea J., Barreiro E. Short- and Long-Term Hindlimb Immobilization and Reloading: Profile of Epigenetic Events in Gastrocnemius. Journal of Cellular Physiology. 2016
• Alvarez-Lerma F., Marin-Corral J., Vila C., Masclans J.R., Gonzalez de Molina F.J., Martin Loeches I. et al. Delay in diagnosis of influenza A (H1N1) pdm09 virus infection in critically ill patients and impact on clinical outcome. Critical Care. 2016;20
• Purificacion P.-T., Jose R.-P., Juan C.R.-R., Roca O., Zapatero A., Gea J. et al. Prospective validation of right ventricular role in primary graft dysfunction after lung transplantation. European Respiratory Journal. 2016;48(6):1732-1742.
• Cosio B.G., Shafiek H., Iglesias A., Yanez A., Cordova R., Palou A. et al. Oral Low-dose Theophylline on Top of Inhaled Fluticasone-Salmeterol Does Not Reduce Exacerbations in Patients With Severe COPD: A Pilot Clinical Trial. Chest. 2016;150(1):123-130.
• Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Gea j et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):-. FI 9.108
Highlights
In 2016 our group has published numerous research papers, highlighting those belonging to its classical research lines (muscle abnormalities in COPD and other chronic diseases, relationships between COPD and lung cancer, and pulmonary hypertension). The incorporation of a senior researcher to our group has added a new line, focused in the study of several disorders present in critically ill patients. Furthermore, the first step of the ‘omics’ analysis from the CIBERES project BIOMEPOC has been carried out. This is one of the main studies of the program on Chronic Respiratory Diseases (COPD line), and has facilitated the extension of our collaborations to bioinformatic groups from other research institutions. There are also collaborations with groups of CIBER BBN, which are focused on the development of instruments
to monitor respiratory muscle function. Regarding translational activities it should be mentioned that
we currently have two patented instruments that are currently commercialized (Europe and America).
On the other hand, in the past year we participated in the elaboration and publication of the SEPAR recommendations for the management of lung cancer patients, and in a guide for the study of autophagy. An important and recent addition to the group has been our second CIBER postdoctoral investigator,
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an action that will undoubtedly boost our future research actions. In terms of projects, two actions were submitted to the EC 2020 Horizon program and both have been positively evaluated in the initial thematic selection. One of them would eventually be coordinated by CIBERES. As for postgraduate teaching, 4 doctoral theses from our group have successfully been defended in 2016, and 5 more are ongoing.
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